Ask The Experts http://randd.canon-experts.com The only place to get expert advice! Thu, 11 Feb 2010 21:14:13 +0000 http://wordpress.org/?v=2.7 en hourly 1 What advantages do microemulsion formulations offer specifically for topical and transdermal drug delivery? http://randd.canon-experts.com/2010/02/what-advantages-do-microemulsion-formulations-offer-specifically-for-topical-and-transdermal-drug-delivery/ http://randd.canon-experts.com/2010/02/what-advantages-do-microemulsion-formulations-offer-specifically-for-topical-and-transdermal-drug-delivery/#comments Thu, 11 Feb 2010 21:14:13 +0000 admin http://randd.canon-experts.com/?p=205 http://randd.canon-experts.com/2010/02/what-advantages-do-microemulsion-formulations-offer-specifically-for-topical-and-transdermal-drug-delivery/feed/ What’s your take on the emergence of chronotherapeutic drug delivery systems, which control drug release according to circadian rhythms and the timing of symptoms? Does this technology offer potential benefit in treating chronic diseases such as ulcers, asthma, and cardiovascular disease, which display time-dependent symptoms? http://randd.canon-experts.com/2010/02/what%e2%80%99s-your-take-on-the-emergence-of-chronotherapeutic-drug-delivery-systems-which-control-drug-release-according-to-circadian-rhythms-and-the-timing-of-symptoms-does-this-technology-offer-p/ http://randd.canon-experts.com/2010/02/what%e2%80%99s-your-take-on-the-emergence-of-chronotherapeutic-drug-delivery-systems-which-control-drug-release-according-to-circadian-rhythms-and-the-timing-of-symptoms-does-this-technology-offer-p/#comments Thu, 11 Feb 2010 21:10:43 +0000 admin http://randd.canon-experts.com/?p=202 http://randd.canon-experts.com/2010/02/what%e2%80%99s-your-take-on-the-emergence-of-chronotherapeutic-drug-delivery-systems-which-control-drug-release-according-to-circadian-rhythms-and-the-timing-of-symptoms-does-this-technology-offer-p/feed/ Are there any ways to ameliorate the cardiac risks of a drug in development, if such risks are detected early enough? Is it possible to “rescue” a drug that exhibits those risks in the early clinical stages? Or should the developer just move on? http://randd.canon-experts.com/2010/01/are-there-any-ways-to-ameliorate-the-cardiac-risks-of-a-drug-in-development-if-such-risks-are-detected-early-enough-is-it-possible-to-rescue-a-drug-that-exhibits-those-risks-in-the-early-clinic/ http://randd.canon-experts.com/2010/01/are-there-any-ways-to-ameliorate-the-cardiac-risks-of-a-drug-in-development-if-such-risks-are-detected-early-enough-is-it-possible-to-rescue-a-drug-that-exhibits-those-risks-in-the-early-clinic/#comments Wed, 27 Jan 2010 17:01:10 +0000 admin http://randd.canon-experts.com/?p=190 http://randd.canon-experts.com/2010/01/are-there-any-ways-to-ameliorate-the-cardiac-risks-of-a-drug-in-development-if-such-risks-are-detected-early-enough-is-it-possible-to-rescue-a-drug-that-exhibits-those-risks-in-the-early-clinic/feed/ What are the prospects for the expanded use of biomarkers in clinical trials to indicate cardiac risks? Are there any accepted biomarkers for cardiac risk at present? What is FDA’s stance on the use of these biomarkers as part of the submission for a drug? http://randd.canon-experts.com/2010/01/what-are-the-prospects-for-the-expanded-use-of-biomarkers-in-clinical-trials-to-indicate-cardiac-risks-are-there-any-accepted-biomarkers-for-cardiac-risk-at-present-what-is-fdas-stance-on-the-use/ http://randd.canon-experts.com/2010/01/what-are-the-prospects-for-the-expanded-use-of-biomarkers-in-clinical-trials-to-indicate-cardiac-risks-are-there-any-accepted-biomarkers-for-cardiac-risk-at-present-what-is-fdas-stance-on-the-use/#comments Wed, 27 Jan 2010 16:59:16 +0000 admin http://randd.canon-experts.com/?p=187 http://randd.canon-experts.com/2010/01/what-are-the-prospects-for-the-expanded-use-of-biomarkers-in-clinical-trials-to-indicate-cardiac-risks-are-there-any-accepted-biomarkers-for-cardiac-risk-at-present-what-is-fdas-stance-on-the-use/feed/ Do you see a discernable increase in demand for formulation development services, particularly in active preclinical formulations where it is often more difficult due to higher dosage levels? http://randd.canon-experts.com/2010/01/do-you-see-a-discernable-increase-in-demand-for-formulation-development-services-particularly-in-active-preclinical-formulations-where-it-is-often-more-difficult-due-to-higher-dosage-levels/ http://randd.canon-experts.com/2010/01/do-you-see-a-discernable-increase-in-demand-for-formulation-development-services-particularly-in-active-preclinical-formulations-where-it-is-often-more-difficult-due-to-higher-dosage-levels/#comments Tue, 19 Jan 2010 15:04:45 +0000 admin http://randd.canon-experts.com/?p=178 http://randd.canon-experts.com/2010/01/do-you-see-a-discernable-increase-in-demand-for-formulation-development-services-particularly-in-active-preclinical-formulations-where-it-is-often-more-difficult-due-to-higher-dosage-levels/feed/ How much promise do new technologies exploring oral insulin analogues – many just entering human testing – have in diabetes drug delivery? Can the traditional hurdles in oral administration be overcome? http://randd.canon-experts.com/2010/01/how-much-promise-do-new-technologies-exploring-oral-insulin-analogues-%e2%80%93-many-just-entering-human-testing-%e2%80%93-have-in-diabetes-drug-delivery-can-the-traditional-hurdles-in-oral-administr/ http://randd.canon-experts.com/2010/01/how-much-promise-do-new-technologies-exploring-oral-insulin-analogues-%e2%80%93-many-just-entering-human-testing-%e2%80%93-have-in-diabetes-drug-delivery-can-the-traditional-hurdles-in-oral-administr/#comments Tue, 19 Jan 2010 14:57:49 +0000 admin http://randd.canon-experts.com/?p=180 http://randd.canon-experts.com/2010/01/how-much-promise-do-new-technologies-exploring-oral-insulin-analogues-%e2%80%93-many-just-entering-human-testing-%e2%80%93-have-in-diabetes-drug-delivery-can-the-traditional-hurdles-in-oral-administr/feed/ What are the one or two, in your opinion, most promising novel imaging techniques emerging in Phase I and II studies, and which therapeutic areas do they have the greatest potential? http://randd.canon-experts.com/2010/01/most-promising-novel-imaging-techniques/ http://randd.canon-experts.com/2010/01/most-promising-novel-imaging-techniques/#comments Thu, 07 Jan 2010 14:47:17 +0000 admin http://randd.canon-experts.com/?p=172 http://randd.canon-experts.com/2010/01/most-promising-novel-imaging-techniques/feed/ What are the chief concerns regulators have regarding the use of data from independent imaging assessment committees in helping make endpoint decisions in oncology trials? http://randd.canon-experts.com/2010/01/independent-imaging-assessment/ http://randd.canon-experts.com/2010/01/independent-imaging-assessment/#comments Thu, 07 Jan 2010 14:45:36 +0000 admin http://randd.canon-experts.com/?p=168 http://randd.canon-experts.com/2010/01/independent-imaging-assessment/feed/ Are the benefits of integrating IVR systems with other study management tools truly being realized, or do companies have a lot more kinks to work out in that area? http://randd.canon-experts.com/2009/10/are-the-benefits-of-integrating-ivr-systems-with-other-study-management-tools-truly-being-realized-or-do-companies-have-a-lot-more-kinks-to-work-out-in-that-area/ http://randd.canon-experts.com/2009/10/are-the-benefits-of-integrating-ivr-systems-with-other-study-management-tools-truly-being-realized-or-do-companies-have-a-lot-more-kinks-to-work-out-in-that-area/#comments Wed, 14 Oct 2009 19:41:06 +0000 admin http://randd.canon-experts.com/?p=163 http://randd.canon-experts.com/2009/10/are-the-benefits-of-integrating-ivr-systems-with-other-study-management-tools-truly-being-realized-or-do-companies-have-a-lot-more-kinks-to-work-out-in-that-area/feed/ Has investigator acceptance of electronically managed drug accountability documentation caught up with their comfort level in other trial technologies, such as EDC? http://randd.canon-experts.com/2009/10/has-investigator-acceptance-of-electronically-managed-drug-accountability-documentation-caught-up-with-their-comfort-level-in-other-trial-technologies-such-as-edc/ http://randd.canon-experts.com/2009/10/has-investigator-acceptance-of-electronically-managed-drug-accountability-documentation-caught-up-with-their-comfort-level-in-other-trial-technologies-such-as-edc/#comments Wed, 14 Oct 2009 19:40:06 +0000 admin http://randd.canon-experts.com/?p=160 http://randd.canon-experts.com/2009/10/has-investigator-acceptance-of-electronically-managed-drug-accountability-documentation-caught-up-with-their-comfort-level-in-other-trial-technologies-such-as-edc/feed/